She-Wolf of London was part of the Hollywood Premiere Network, an early attempt by Universal Television to create an "ad-hoc" syndication network. The series premiered along with two other shows, Shades of L.A. and They Came from Outer Space on October 9, 1990. The package aired on many of the stations that would later become either UPN or WB affiliates.
The series included female nudity in some episodes, something not uncommon to European television, but something considered taboo for U.S. non-cable television programming.
Midway through the first season, the European producers of the series pulled their financial backing, and the lower budget forced production to move to Los Angeles for the final six episodes. The series was retitled Love and Curses; Neil Dickson's character was dismissed from his position as a British professor and moved to L.A. to become the host of a talk show investigating the paranormal (explained by the success of one of his books after it was issued with a trashy mass market title). The joint UK/US production ended after its first season, along with the cancellation of two other Hollywood Premiere Network shows.
Episodes of the series ran on the Sci-Fi Channel for a short time following its cancellation. For these airings, the Love and Curses episodes were retitled She-Wolf of London. The opening sequence for these episodes were replaced by the show's original opening. These episodes were also retitled when run in Britain on Sky One, with the opening moments of the She-Wolf titles used to establish the series' title logo, before the titles cut to the Love and Curses opening credits sequence.
It was announced November 18, 2009 that all 20 episodes would be released in a complete series box set from Universal Studios Home Entertainment. Included are the six episodes from the 2nd season that was retitled "Love and Curses". She-Wolf of London: Love and Curses was released on February 2, 2010 as a 4-disc set. The boxed set contains no extras and the opening credits of the series were changed. While originally, the "She-wolf of London" episodes had a different theme from the L.A.-based "Love and Curses" episodes, all episodes in the boxed set begin with the "Love and Curses" theme.